منابع مشابه
Physicochemical evaluation of lyophilized formulation of p-SCN-Bn-DOTA-and p-SCN-Bn-DTPA-rituximab for NHL radioimmunotherapy
Radioimmunotherapy (RIT) of Non-Hodgkin’s lymphoma (NHL) is said to be more advantageous compared to unlabelled therapeutic antibodies. To this date, radiolabelled murine anti-CD20 mAbs, Zevalin® and Bexxar® have been approved for imaging and therapy. A preparation containing rituximab, chimeric mAb radioimmunoconjugate suitable for Lu-177 labeling, could provide better imaging and therapeutic ...
متن کاملWhat is the role of maintenance rituximab in follicular NHL?
Recent trials have demonstrated improvements in progression-free and overall survival with the inclusion of the chimeric anti-CD20 monoclonal antibody rituximab (Rituxan) in chemotherapy regimens for treatment-naive and relapsed patients with advanced-stage follicular non-Hodgkin's lymphoma (NHL). As rituximab therapy has significant single-agent activity infollicular NHL, is generally well tol...
متن کاملComplement activation and rituximab distribution in CNS NHL--letter.
We have read with great interest the article by Kadoch and colleagues (1). Their pharmacokinetic model indicates rapid distribution of intraventricular rituximab from cerebrospinal fluid (CSF) into neural tissues and serum. These findings may have more general implications for intrathecal (IT) immunotherapy with monoclonal antibodies. IT trastuzumab was safe and effective in HER2-positive lepto...
متن کاملPhysicochemical evaluation of lyophilized formulation of p-SCN-Bn-DOTA-and p-SCN-Bn-DTPA-rituximab for NHL radioimmunotherapy
Radioimmunotherapy (RIT) of Non-Hodgkin’s lymphoma (NHL) is said to be more advantageous compared to unlabelled therapeutic antibodies. To this date, radiolabelled murine anti-CD20 mAbs, Zevalin® and Bexxar® have been approved for imaging and therapy. A preparation containing rituximab, chimeric mAb radioimmunoconjugate suitable for Lu-177 labeling, could provide better imaging and therapeutic ...
متن کاملIntrapleural instillation of rituximab for the treatment of malignant pleural effusions in NHL.
A patient with CD20(+) leukaemic lymphoplasmacytic Non-Hodgkin's lymphoma (NHL) presented with bilateral malignant pleural effusions. Systemic chemotherapy, repeated percutaneous drainage and bilateral continous chest tube drainage were unable to control the effusions. Rituximab was instilled in a dose-escalating manner via the chest tubes into both pleural spaces, within two weeks the effusion...
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ژورنال
عنوان ژورنال: Nature Reviews Clinical Oncology
سال: 2020
ISSN: 1759-4774,1759-4782
DOI: 10.1038/s41571-020-0409-8